Okay keep this under wraps....not an official flying technique.
Here's a formula I use for the high altitude airports like AS-Quito and AS-Cuzco.
-FE Active but not in control of Turbos or MP Hold.
-Master Prop Sync lever at 90%. Will yield 2550rpms at full throttle.
-Turbo Control Override switches @ Climb & Cruise
-Turbo Boost Selector @ 30%-50%
-To find the best Turbo setting, I do a run up just prior to take-off. I want to be able to reach 55"MP if needed + leave a little overhead. If it looks like there is room, I try to throttle back to 51" before breaking ground, just to get the temps back down as soon as possible.
I fly 99.9% of all 377 flights at MTOW/72 passengers and came up with this so I could still fly maxed out from the really tricky high altitude airports and not tear up the engines.
Take-off from AS Quito @ MTOW/72. I started this flight on the runway. On a normal flight, she would have burned off a few of these pounds during the taxi.
Easily off the ground with room to spare. She was already on auto-pilot by the time I crossed the wall at the end of the runway.